Carcinogenesis, Teratogenesis & Mutagenesis ›› 2003, Vol. 15 ›› Issue (2): 101-103.doi: 10.3969/j.issn.1004-616x.2003.02.012

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STUDY ON ANTIMUTAGENICITY OF CHINESE HERBAL MEDICINE AND GREEN TEA TO BENZOAPYRENE AND NNK

ZHANG Chun-ling, HU Jun-feng, QU Jiang-bin, et al.   

  1. School of Public Health, Shandong University, Jinan 250012 , China
  • Received:2002-07-29 Revised:2002-10-12 Online:2003-04-30 Published:2003-04-30
  • Contact: ZHANG Chun-ling

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Abstract: Purpose: To investigate the antimutagenicity of water extract of green tea, tea polyphenol, Scutellaria barbata D. Don, Hedyotis diffusa wildi and Xihuangwan to benzoapyrene[B(a)P] and 4-methylnitrosamino-1-(3-pyridy)-1-butanone(NNK). Methods: The Ames test was used in this study. Results: Except the lowest dosage group, all the other dosage groups of green tea, tea polyphenol, Scutellaria barbate,Hedyotis diffusa wildi and Xihuangwan inhibited the reverse mutation of TA 98 and TA 100 induced by B(a)P and NNK significantly(P<0.01). Conclusion: The tested Chinese herbal medicines and green tea have antimutagenicity to B(a)P and NNK, and there is a dose-effect relationship.

Key words: antimetagenicity, chinese herbal medicine, green tea, B(a)P, NNK